| 名稱 | ADCC Bioassay Effector Cell F variant (Low Affinit |
| 型號(hào) | CBP74002 |
| 報(bào)價(jià) | ![]() |
| 特點(diǎn) | ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat,母細(xì)胞:Jurkat,培養(yǎng)基:1640+10%FBS |
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74002ADCC Bioassay Effector Cell F variant (Low Affinit
- 詳細(xì)內(nèi)容
| I. Background | |
抗體依賴的細(xì)胞介導(dǎo)的細(xì)胞毒性作用(ADCC,antibody-dependent cell-mediated cytotoxicity )是指抗體的 Fab 段結(jié)合病毒感染的細(xì)胞或腫瘤細(xì)胞的抗原表位,其 Fc 段與殺 傷細(xì)胞(NK 細(xì)胞、巨噬細(xì)胞等)表面的 FcR 結(jié)合,介導(dǎo)殺傷細(xì)胞直接殺傷靶細(xì)胞,它是 抗腫瘤的治療性抗體藥物發(fā)生作用的一種作用重要機(jī)制。 | |
| II. Description | |
ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat 報(bào)告基因藥靶模型 很好的模擬了體內(nèi) ADCC 的信號(hào)轉(zhuǎn)導(dǎo)過(guò)程,原理見下圖所示。
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| III. Introduction | |
| Host Cell: | Jurkat |
| Expressed gene: | NFAT-Luc-CD16(F158) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Antibody-dependent cell-mediated cytotoxicity |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS |
| Mycoplasma Testing: | Negative |
| Storage: | Immediately upon receipt, store in liquid nitrogen. |
| Application(s): | Functional(Report Gene) Assay |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Peripheral blood |
| Disease: | Acute T cell leukemia |
| Morphology: | Lymphoblast |
| Growth Properties: | Suspension |
| Ⅴ. Representative Data | |

Figure 2. Recombinant ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat expressing CD16.

Figure 3. Dose response of CD20 Ab in ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat (C11) with Raji.





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